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Ebook Neural Control of Renal Function (Integrated Systems Physiology From Molecule to Function to)

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Published on: 2011-07-01
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Original language: English

The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Activation of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension. Table of Contents: Part I: Efferent Renal Sympathetic Nerves / Introduction / Neuroanatomy / Neural Control of Renal Hemodynamics / Neural Control of Renal Tubular Function / Neural Control of Renin Secretion Rate / Part II: Afferent Renal Sensory Nerves / Introduction / Neuroanatomy / Renorenal Reflexes / Mechanisms Involved in the Activation of Afferent Renal Sensory Nerves / Part III: Pathophysiological States / Efferent Renal Sympathetic Nerves / Afferent Renal Sensory Nerves / Conclusions / References Free Physiology Books Download Ebooks Online Textbooks This eBook series on the broad field of physiology explains the major organ systems from an integrative perspective that addresses the molecular and cellular ... AMPK Suppresses Connexin43 Expression in the Bladder and ... AMPK suppresses Cx43 expression and function. We stimulated BSMCs with three different AMPK agonists to determine the potential role of AMPK in Cx43 expression. Dr. Calapai's Nutritional Medicine practice: Prolotherapy ... Watch Dr. Calapai's new TV Show "Dr. Cal's Healthy Living" every Saturday 11:30 AM on channel 55 or 10 locally and America 1 Nationally Natriuretic Peptides NEJM Review Article. Mechanisms of Disease. Franklin H. Epstein M.D. Editor. Natriuretic Peptides. Ellis R. Levin M.D. David G. Gardner M.D. and Willis K. Samson Ph.D. Ontogeny Anatomy Metabolism and Physiology of the ... ABSTRACT. This chapter presents an analysis and a summarized synthesis of our present knowledge of the biology of the thyroid gland phylogeny ontogeny ... Theses and Dissertations Available from ProQuest Theses ... Theses and Dissertations Available from ProQuest. Full text is available to Purdue University faculty staff and students on campus through this site. Resolve a DOI Name Type or paste a DOI name into the text box. Click Go. Your browser will take you to a Web page (URL) associated with that DOI name. Send questions or comments to doi ... Lecture Notes on Cardiovascular Pathophysiology - Helmberg Angiotensin converting enzyme (ACE) is an integral membrane protein that is shed from the surface with the help of a metalloprotease. Both integrated and soluble ... Research in Edinburgh funded by Medical Research Scotland Medical Research Scotland is an independent charity which funds biomedical research in Scotland from donations and bequests. We support research into any disease by ... The Enteric Nervous System NEJM The enteric nervous system is a collection of neurons in the gastrointestinal tract1 that constitutes the brain of the gut and can function independently of the ...
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